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What to expect after a PRP injection

  • Once the local anesthetic wears off, the area surrounding the injection site may be throbbing and aching. Remember, the theory behind platelet rich plasma injections is using platelets to trick your body into thinking you just injured yourself, therefore triggering a regenerative response from your body.  This will hopefully replace chronic inflammation with a short period of acute inflammation and will also stabilize the tissues in the affected area.
  • The area may be aching and throbbing for at least 24 hours, and this could last for up to one week.
  • If the pain is causing trouble sleeping, you can use Tylenol or your prescribed pain medication.
  • It is common and expected to feel an achy and stiff sensation of fullness at the injection site that may last for several days. The fullness is due to the platelet gel forming a matrix that takes up space within the tissue.
  • In the weeks following the injection, we typically hear that people have good and bad days. Remember, this is not a steroid injection, which tends to show a rapid effect.  Most of our patients see the most benefit approximately 4-6 weeks post injection.  We ask that you follow-up at our office in 4 weeks to monitor your progress.

Medication Guidelines

  • For a minimum of two weeks post-injection, it is important for the efficacy of the treatment that all anti-inflammatory medications (NSAIDS) are discontinued. You can take Tylenol (Acetaminophen) and Celebrex, but we ask that you avoid other NSAIDS such as aspirin, Naproxen (Aleve) and Ibuprofen (Advil, Motrin) because they will inhibit platelet function.  Other prescription medication should be reviewed with your procedure physician.
  • Apply moist heat to treated area for the first 24 hours.

Activity Guidelines

  • FIRST WEEK…Treated areas should remain immobile.
  • For the first two weeks, we encourage you to resume normal day-to day activities…BUT NO exercise of the treated extremity.
  • SECOND WEEK… light exercises and progressively build back to normal exercise after 4 weeks. Controlled and moderate movement is important for the proper stimulation of tissue to rebuild in a linear and physiologic fashion.  However, we strongly advise that you avoid heavy lifting or high exercise levels because these activities will compromise the progress we are trying to make
  • AFTER TWO WEEKS…you are cleared by your physician to resume exercising the area. However, we ask that you gradually increase the intensity of your workouts so as not to re-injure the tissue. Use pain in the area of injection as a guide to how far you push yourself.  This is not like physical therapy after surgery. We do not want you to push through the pain.  Instead, ease off the intensity if the pain persists.
  • If you feel any of the following symptoms immediately contact our office: prolonged redness, swelling, fevers, chills, muscle weakness as well as numbness and/or tingling.

Additional injections

  • Depending upon how the tissue reacts to the initial PRP injection, you may need an additional injection. An evaluation will be done to see if the tissue is responding before a second procedure is planned. Your treatment plan will be discussed in detail following your injection.

Read More about Conditions Treated with PRP