Stem Cell

Stem Cell Therapy: The Alternative to Knee Replacement / RESEARCH in PLATELET RICH PLASMA (PRP) Injections

  1. Several studies have revealed under ultrasound that there are changes in tendon size (decrease) and good architectural changes suggesting that structural changes may occur after treatment with PRP.
  2. PRP is an effective and safe treatment for patients with chronic tendinopathy in a variety of locations to include, achilles tendon, lateral epicondylitis, the patella tendon, and several other tendons.
  3. In a major study by Finnoff et al of patients injected with PRP:
    1. 83% of subjects were satisfied with their outcome after the procedure.
    2. 83% would recommend the procedure to a friend.
    3. 82% had an improvement in the ultrasound analysis of the tendon echotexture.
    4. 82% had a decrease in the tendon vascularity.
    5. 38% had resolution of the intra-tendinous calcifications.
    6. No complications were reported.
    7. There was a mean improvement in the subjects function and worse pain scores of 68% and 58% respectively.
    8. In conclusion, Finoff’s study demonstrated improvements not only in pain but also in function and tendon structure after the PRP procedure. His study used tenotomy followed by PRP injection, then followed by a standardized post – procedural rehabilitation program.

PRP AND BONE

  1. Plachokova et al 2008 – –
    • PRP and bone regeneration in dentistry found evidence of the beneficial effects of PRP in the treatment of periodontal defects.

PRP AND MUSCLES

  1. PRP for treatment of hamstrings injuries – – Hamid et al – – American Journal of Sports Medicine 2014.
    • RESULTS – – A single autologous PRP injection combined with a rehab program was significantly more effective in treating hamstring injuries then a rehab program alone.

PRP AND TENDON

  1. Treatment of chronic severe elbow tendinosis with PRP – – Mishra et al 2006.
    1. RESULTS
      1. PRP treated patients showed significant improvement with a single injection that was sustained over time.
      2. No side effects.
      3. Significantly reduced pain (at 6 months post injection . . . 81% decreased pain).
      4. Mayo Clinic elbow scores improved 72% at 6 months post injection.
      5. Consider PRP before surgery was the conclusion of the paper.
  2. Treatment of Achilles tendinopathy with PRP – – Gaweda et al – – International Journal of Sports Medicine 2010.
    1. RESULTS – – PRP improved symptoms of non-insertional tendinopathy, pain scores, and the American
      Academy of Orthopedic Foot and Ankle Surgery scores improved for achilles tendinopathy with PRP.
  3. PRP for jumper’s knee – – Kon, Filardo 2009
    1. RESULTS – – Statistically significant improvement in all scores at 6 months follow up injection for jumper’s knee:
      1. Pain levels decreased.
      2. Sports activity levels increased.
      3. Percent of participants resuming sports after treatment increased.

 

PRP AND LIGAMENT

  1. Joshi . . Murray . . American Journal of Sports Medicine 2009
    • The addition of collagen – platelet composite used to supplement suture repair of an ACL repair enhanced the structural properties of the ACL, and the improvement is associated with increased cellularity within the healing ligament.

PRP AND CARTILAGE

  1. Ultrasound guided PRP injections for treatment of hip osteoarthritis – – Sanchez et al – Rheumatology 2011
    1. RESULTS – – Significant reductions at 7 months and 6 months seen in the following:
      1. VAS (pain scores).
      2. WOMAC score.
      3. Harris Hip Score for pain and function.
  2. PRP and knee arthritis – – Filardo and Kon 2011 (Knee Surgery for Sports Traumatol Arthroscopy – 2011)
    1. 114 knees injected with PRP in 91 patients with knee arthritis.
    2. RESULTS – –
      1. 78% improved after treatment.
      2. 73% improved after 6 months.
      3. 67% improved at 12 months.
      4. 54% improved at 24 months.
  3. Clinical and MRI outcomes after PRP treatment for early knee osteoarthritis – – Halpern et al – – Clinical Journal of Sports Medicine 2013.
    1. RESULTS – – Evaluation after one year with the following results:
      1. Pain scores significantly decreased.
      2. Functional scores and clinical scores increased.
      3. No MRI changes.
  4. Injection of PRP in patients with primary and secondary knee osteoarthritis – – Sampson et al – American Journal of Physcial Medicine and Rehabilitation, December 2010
    1. Three PRP injections of the knee at 4 week intervals.
    2. 52 weeks follow up.
    3. VAS – – Improvements with movement and rest activities.
      1. Improved expectation score and knee injury showed good improvement.
      2. Osteoarthritis outcome scores showed very good improvements.
      3. Sampson Found PRP works best in active patients with mild/moderate osteoarthritis of the knee
      4. Early Intervention for mild/moderate osteoarthritis is the key

 

PRP AND NERVE

  1. Efficacy of epidural perineural injections with autologous conditioned serum for lumbar radicular compression . . Cordelia Becker . . Spine 2007
    1. RESULTS – – Autologous conditioned serum injection for lumbar radicular compression showed significant decrease in pain and decreased disability (and thusly superior to steroid injections from weeks 12 – – to 22 weeks).

 

Posted in: research

Comments are currently closed.

Top