Stem Cell

for Knee Pain

Osteoarthritis is the most common form of knee arthritis.

Osteoarthritis is the most common form of knee arthritis.

Knee Osteoarthritis

Degenerative arthritis most commonly affects patients ages 55 years and older. It is associated with obesity and family history. The onset of pain is slow and is associated with pain with activity in the early stages, and then in the later stages pain can even occur at rest.

Osteoarthritis is the most common form of knee arthritis and can involve all three components in the knee:

  1. The medial compartment.
  2. The lateral compartment.
  3. The patellofemoral compartment.

The medial compartment is the most commonly injured in the knee. There is also an increased risk of osteoarthritis after meniscus or ACL injury.

The knee joint is a relatively complex anatomical structure. Ligaments, cartilage and muscles maintain stability. The knee is used in almost all lower extremity motion and can eventually degenerate from overuse. If left untreated, the pain can be intolerable. Reducing the pain from osteoarthritis, rheumatoid arthritis, partial meniscal tears, ACL and PCL tears may be possible through STEM CELL therapy.




Patients with end-stage arthritis have pain on weight bearing, a sensation of buckling or giving way of the knee, stiffness and joint swelling. These symptoms can limit motion of

Arthritic Knee (LEFT) vs Normal Knee (RIGHT)

Arthritic Knee (LEFT) vs Normal Knee (RIGHT)

the knee at both extremes of flexion and extension. Patients often report symptoms of locking or catching due to sticking of the rough joint surfaces and/or inflamed soft tissues surrounding the knee.


A limp, episodes of falling, chronic pain, and a loss of knee function with weight bearing and walking may develop. The patient can become more sedentary secondary to pain and symptoms.



  1. Nonsteroidals/Tylenol
  2. Ice, heat, liniments.
  3. Splints.
  4. Bracing.
  5. Physical therapy – bicycling and water aerobics can maintain strength and motion.
  6. A cane.
  7. Steroid injections to the knee
  8. Surgery.
The knee joint is a relatively complex anatomical structure.

The knee joint is a relatively complex anatomical structure.

See what conditions can be treated with STEM CELL Therapy

What to expect after STEM CELL Therapy


THE STEM CELL ORTHOPEDIC INSTITUTE OF TEXAS offers STEM CELL injections for those suffering from knee pain or for those that need knee surgery or a total knee replacement. Candidates for STEM CELL treatment may have knee problems such as tendon, ligament, bone injury, arthritis and other degenerative conditions. Early intervention for mild/moderate osteoarthritis is the key.

If you have an injury to the knee to include the meniscus, knee cartilage, ACL or MCL ligaments or chronic arthritis – – – You may be a good candidate for STEM CELLS.

If you are told by your physician (Orthopedist, Physical Medicine and Rehabilitation, or Rheumatologist) that you need arthroscopic knee surgery or a total knee replacement you may be a candidate for STEM CELLS.

Osteoarthritis is the most common type of osteoarthritis characterized by degeneration of the articular cartilage and ultimately joint destruction.

Osteoarthritis is the most common type of osteoarthritis characterized by degeneration of the articular cartilage and ultimately joint destruction.

Surgery requires months of rehabilitation to regain strength and range of motion. Post-operative pain and surgical risks are also problematic. A new study of 2,400 patients with knee or hip replacements showed that only 50% of patients report a significant improvement in pain and their activities of daily living. It was also found that 25% of patients who undergo a single joint replacement will require another joint replaced within 2 years.

STEM CELL treatment may be an alternative to knee surgery or knee replacement. This may alleviate knee pain, improve your quality of life, increase knee cartilage growth and help repair ligament damage and reduce recovery time significantly.

The STEM CELL injection is a one day injection treatment, and patients are encouraged to walk that same day with little to no down time from work.

Read more on the essential need for using Ultrasound when receiving STEM CELL therapy


RESEARCH Regarding Adult STEM CELL TREATMENT for Knee Problems

I. Centeno et al 2008

  1. Knee osteoarthritis treated successfully with MESENCHYMAL STEM CELLS using platelet lysate technique.
    1. Decreased VAS by 95%.
    2. Increased range of motion by 5 degrees.
    3. Increase in cartilage growth by 19% as measured by MRI at 6 months follow up.

II. Intra-articular injection of Autologous MESENCHYMAL STEM CELLS in 6 patient with osteoarthritis (No Growth Factors added) – – Emadedin et al 2012

  1. 50% showed (after 1 year on MRI) the following;
    1. An increase in cartilage thickness.
    2. Extension of repair tissue over subchondral bone.
    3. Decrease in subchondral edema.

III. Centeno Registry for Osteoarthritis of the Knee.

  • N = 999 procedures.
  • Age median = 55.5.
  • BMI = 26.8.
  • Mean Improvement of All Patients.
    1 month      3       6       12       24       36       48 months
    38%          45%  53%   53%   52%     69%   71%
  • Mean Improvement for Patients reporting > 50% Improvement.
    1 month      3       6       12       24       36       48 months
    48%          55%  66%   64%   65%     70%    90%




CONCLUSIONS to the Centeno Registry that had STEM CELL injections:

  1. Women in more pain to start with have more increase in function and pain relief.
  2. No association between older age and outcome.
  3. No association between body weight and outcome.
  4. Having a BMI greater than 25 or 30 did not affect the outcome versus normal weight patients (BMI 18 to 25).
  5. No association between arthritis severity and outcome.
  6. Patients with arthritis in many joints have a less robust outcome.
  7. Arthritis in 3 or > joints did reduce the likelihood of success after knee treatment.
  8. Females reported better outcomes in the lower extremity function and pain scores.
  9. Most improvement for pain was seen at 3 years post injection of STEM CELLS.
  10. Having a second knee procedure injected with STEM CELLS significantly improved the pain scores.  – – The patients who responded to a second procedure achieved approximately 50% more improvement relative to the first procedure with STEM CELLS




  • Patellofemoral syndrome
    • STEM CELL treatment has been promising


  • Total Knee Replacement
    • STEM CELL injections may be an alternative


  • ACL Tears
    • STEM CELL therapy may heal the damage Ligament without surege


Read More

Stem Cell Therapy: The Alternative to Knee Replacement

5 Things Runners Ought to Know About Knees

The 4 Stages of Knee Osteoarthritis

Osteoarthritis and Treatments Options