Osteoarthritis and Treatments Options / RESEARCH Regarding Adult STEM CELL TREATMENT for Knee Problems

I. Centeno et al 2008

  1. Knee osteoarthritis treated successfully with MESENCHYMAL STEM CELLS using platelet lysate technique.
    1. Decreased VAS by 95%.
    2. Increased range of motion by 5 degrees.
    3. Increase in cartilage growth by 19% as measured by MRI at 6 months follow up.

II. Intra-articular injection of Autologous MESENCHYMAL STEM CELLS in 6 patient with osteoarthritis (No Growth Factors added) – – Emadedin et al 2012

  1. 50% showed (after 1 year on MRI) the following;
    1. An increase in cartilage thickness.
    2. Extension of repair tissue over subchondral bone.
    3. Decrease in subchondral edema.

III. Centeno Registry for Osteoarthritis of the Knee.

  • N = 999 procedures.
  • Age median = 55.5.
  • BMI = 26.8.
  • Mean Improvement of All Patients.
    1 month      3       6       12       24       36       48 months
    38%          45%  53%   53%   52%     69%   71%
  • Mean Improvement for Patients reporting > 50% Improvement.
    1 month      3       6       12       24       36       48 months
    48%          55%  66%   64%   65%     70%    90%

 

 

 

CONCLUSIONS to the Centeno Registry that had STEM CELL injections:

  1. Women in more pain to start with have more increase in function and pain relief.
  2. No association between older age and outcome.
  3. No association between body weight and outcome.
  4. Having a BMI greater than 25 or 30 did not affect the outcome versus normal weight patients (BMI 18 to 25).
  5. No association between arthritis severity and outcome.
  6. Patients with arthritis in many joints have a less robust outcome.
  7. Arthritis in 3 or > joints did reduce the likelihood of success after knee treatment.
  8. Females reported better outcomes in the lower extremity function and pain scores.
  9. Most improvement for pain was seen at 3 years post injection of STEM CELLS.
  10. Having a second knee procedure injected with STEM CELLS significantly improved the pain scores.  – – The patients who responded to a second procedure achieved approximately 50% more improvement relative to the first procedure with STEM CELLS

 

ANECDOTAL STUDIES WITH STEM CELLS FOR KNEE PAIN

 

  • Patellofemoral syndrome
    • STEM CELL treatment has been promising

 

  • Total Knee Replacement
    • STEM CELL injections may be an alternative

 

  • ACL Tears
    • STEM CELL therapy may heal the damage Ligament without surege

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